Voltage-sensing phosphatase: its molecular relationship with PTEN.
نویسندگان
چکیده
Voltage-sensing phosphoinositide phosphatase (VSP) contains voltage sensor and cytoplasmic phosphatase domains. A unique feature of this protein is that depolarization-induced motions of the voltage sensor activate PtdIns(3,4,5)P(3) and PtdIns(4,5)P(2) phosphatase activities. VSP exhibits remarkable structural similarities with PTEN, the phosphatase and tensin homolog deleted on chromosome 10. These similarities include the cytoplasmic phosphatase region, the phosphoinositide binding region, and the putative membrane interacting C2 domain.
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ورودعنوان ژورنال:
- Physiology
دوره 26 1 شماره
صفحات -
تاریخ انتشار 2011